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News 244 Publications 8 Members

FOXE3 contributes to Peters anomaly through transcriptional regulation of an autophagy-associated protein termed DNAJB1.... PDF available through Get Fulltext Research

Khan, Shahid Y Vasanth, Shivakumar Kabir, Firoz Gottsch, John D Khan, Arif O Chaerkady, Raghothama Lee, Mei-Chong W Leitch, Carmen C Ma, Zhiwei Laux, Julie ...

Published in Nature communications

FOXE3 is a lens-specific transcription factor that has been associated with anterior segment ocular dysgenesis. To determine the transcriptional target(s) of FOXE3 that are indispensable for the anterior segment development, we examined the transcriptome and the proteome of cells expressing truncated FOXE3 responsible for Peters anomaly identified ...

Agarose- and alginate-based biopolymers for sample preparation: Excellent green extraction tools for this century.

Sanagi, Mohd Marsin Loh, Saw Hong Wan Ibrahim, Wan Nazihah Pourmand, Neda Salisu, Ahmed Wan Ibrahim, Wan Aini Ali, Imran

Published in Journal of separation science

Recently, there has been considerable interest in the use of miniaturized sample preparation techniques before the chromatographic monitoring of the analytes in unknown complex compositions. The use of biopolymer-based sorbents in solid-phase microextraction techniques has achieved a good reputation. A great variety of polysaccharides can be extrac...

Fitting Frequency-Lowering Signal Processing Applying the American Academy of Audiology Pediatric Amplification Guidelin...

Scollie, Susan Glista, Danielle Seto, Julie Dunn, Andrea Schuett, Brittany Hawkins, Marianne Pourmand, Nazanin Parsa, Vijay

Published in Journal of the American Academy of Audiology

Although guidelines for fitting hearing aids for children are well developed and have strong basis in evidence, specific protocols for fitting and verifying technologies can supplement such guidelines. One such technology is frequency-lowering signal processing. Children require access to a broad bandwidth of speech to detect and use all phonemes i...

Fitting Noise Management Signal Processing Applying the American Academy of Audiology Pediatric Amplification Guideline:...

Scollie, Susan Levy, Charla Pourmand, Nazanin Abbasalipour, Parvaneh Bagatto, Marlene Richert, Frances Moodie, Shane Crukley, Jeff Parsa, Vijay

Published in Journal of the American Academy of Audiology

Although guidelines for fitting hearing aids for children are well developed and have strong basis in evidence, specific protocols for fitting and verifying some technologies are not always available. One such technology is noise management in children's hearing aids. Children are frequently in high-level and/or noisy environments, and many options...

A Novel Secreted Protein, MYR1, Is Central to Toxoplasma's Manipulation of Host Cells. PDF available through Get Fulltext Research

Franco, Magdalena Panas, Michael W Marino, Nicole D Lee, Mei-Chong Wendy Buchholz, Kerry R Kelly, Felice D Bednarski, Jeffrey J Sleckman, Barry P Pourmand, Nader Boothroyd, John C ...

Published in mBio

The intracellular protozoan Toxoplasma gondii dramatically reprograms the transcriptome of host cells it infects, including substantially up-regulating the host oncogene c-myc. By applying a flow cytometry-based selection to infected mouse cells expressing green fluorescent protein fused to c-Myc (c-Myc-GFP), we isolated mutant tachyzoites defectiv...

Transcriptome Profiling of Developing Murine Lens Through RNA Sequencing.

Khan, Shahid Y Hackett, Sean F Lee, Mei-Chong W Pourmand, Nader Talbot, C Conover Jr Riazuddin, S Amer

Published in Investigative ophthalmology & visual science

Transcriptome is the entire repertoire of transcripts present in a cell at any particular time. We undertook a next-generation whole transcriptome sequencing approach to gain insight into the transcriptional landscape of the developing mouse lens. We ascertained mouse lenses at six developmental time points including two embryonic (E15 and E18) and...

Optimized Protocol for Simple Extraction of High-Quality Genomic DNA from Clostridium difficile for Whole-Genome Sequenc... PDF available through Get Fulltext Research

Sim, James Heng Chiak Anikst, Victoria Lohith, Akshar Pourmand, Nader Banaei, Niaz

Published in Journal of clinical microbiology

Successful sequencing of the Clostridium difficile genome requires high-quality genomic DNA (gDNA) as the starting material. gDNA extraction using conventional methods is laborious. We describe here an optimized method for the simple extraction of C. difficile gDNA using the QIAamp DNA minikit, which yielded high-quality sequence reads on the Illum...

Confirmation of the cellular targets of benomyl and rapamycin using next-generation sequencing of resistant mutants in S...

Wride, Dustin A Pourmand, Nader Bray, Walter M Kosarchuk, Jacob J Nisam, Sean C Quan, Tiffani K Berkeley, Ray F Katzman, Sol Hartzog, Grant A Dobkin, Carlos E ...

Published in Molecular bioSystems

Investigating the mechanisms of action (MOAs) of bioactive compounds and the deconvolution of their cellular targets is an important and challenging undertaking. Drug resistance in model organisms such as S. cerevisiae has long been a means for discovering drug targets and MOAs. Strains are selected for resistance to a drug of interest, and the res...

Single-cell analyses of transcriptional heterogeneity during drug tolerance transition in cancer cells by RNA sequencing...

Lee, Mei-Chong Wendy Lopez-Diaz, Fernando J Khan, Shahid Yar Tariq, Muhammad Akram Dayn, Yelena Vaske, Charles Joseph Radenbaugh, Amie J Kim, Hyunsung John Emerson, Beverly M Pourmand, Nader ...

Published in Proceedings of the National Academy of Sciences of the United States of America

The acute cellular response to stress generates a subpopulation of reversibly stress-tolerant cells under conditions that are lethal to the majority of the population. Stress tolerance is attributed to heterogeneity of gene expression within the population to ensure survival of a minority. We performed whole transcriptome sequencing analyses of met...

You cannot tell a book by looking at the cover: Cryptic complexity in bacterial evolution.

Zhang, Qiucen Bos, Julia Tarnopolskiy, Grigory Sturm, James C Kim, Hyunsung Pourmand, Nader Austin, Robert H

Published in Biomicrofluidics

Do genetically closely related organisms under identical, but strong selection pressure converge to a common resistant genotype or will they diverge to different genomic solutions? This question gets at the heart of how rough is the fitness landscape in the local vicinity of two closely related strains under stress. We chose a Growth Advantage in S...

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