UC Santa Cruz Nanotechnology Cluster
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News 244 Publications 8 Members

Correlated electrical and optical analysis of single nanoparticles and biomolecules on a nanopore-gated optofluidic chip... PDF available through Get Fulltext Research

Liu, Shuo Zhao, Yue Parks, Joshua W Deamer, David W Hawkins, Aaron R Schmidt, Holger

Published in Nano letters

The analysis of individual biological nanoparticles has significantly advanced our understanding of fundamental biological processes but is also rapidly becoming relevant for molecular diagnostic applications in the emerging field of personalized medicine. Both optical and electrical methods for the detection and analysis of single biomolecules hav...

Compartmental genomics in living cells revealed by single-cell nanobiopsy.

Actis, Paolo Maalouf, Michelle M Kim, Hyunsung John Lohith, Akshar Vilozny, Boaz Seger, R Adam Pourmand, Nader

Published in ACS nano

The ability to study the molecular biology of living single cells in heterogeneous cell populations is essential for next generation analysis of cellular circuitry and function. Here, we developed a single-cell nanobiopsy platform based on scanning ion conductance microscopy (SICM) for continuous sampling of intracellular content from individual ce...

Carbohydrate-actuated nanofluidic diode: switchable current rectification in a nanopipette.

Vilozny, Boaz Wollenberg, Alexander L Actis, Paolo Hwang, Daniel Singaram, Bakthan Pourmand, Nader

Published in Nanoscale

Nanofluidic structures share many properties with ligand-gated ion channels. However, actuating ion conductance in artificial systems is a challenge. We have designed a system that uses a carbohydrate-responsive polymer to modulate ion conductance in a quartz nanopipette. The cationic polymer, a poly(vinylpyridine) quaternized with benzylboronic ac...

Frac-seq reveals isoform-specific recruitment to polyribosomes.

Sterne-Weiler, Timothy Martinez-Nunez, Rocio Teresa Howard, Jonathan M Cvitovik, Ivan Katzman, Sol Tariq, Muhammad A Pourmand, Nader Sanford, Jeremy R

Published in Genome research

Pre-mRNA splicing is required for the accurate expression of virtually all human protein coding genes. However, splicing also plays important roles in coordinating subsequent steps of pre-mRNA processing such as polyadenylation and mRNA export. Here, we test the hypothesis that nuclear pre-mRNA processing influences the polyribosome association of ...

Distinctive microRNA expression signatures in proton-irradiated mice

Khan, Shahid Yar Tariq, Muhammad Akram Perrott, James Patrick Brumbaugh, Christopher Drew Kim, Hyunsung John Shabbir, Muhammad Imran Ramesh, Govindarajan T. Pourmand, Nader

Published in Molecular and Cellular Biochemistry

Proton particles comprise the most abundant ionizing radiation (IR) in outer space. These high energy particles are known to cause frequent double- and single-stranded DNA lesions that can lead to cancer and tumor formation. Understanding the mechanism of cellular response to proton-derived IR is vital for determining health risks to astronauts dur...

Crystal structure of the avian astrovirus capsid spike. PDF available through Get Fulltext Research

DuBois, Rebecca M Freiden, Pamela Marvin, Shauna Reddivari, Muralidhar Heath, Richard J White, Stephen W Schultz-Cherry, Stacey

Published in Journal of virology

Astroviruses are small, nonenveloped, single-stranded RNA viruses that cause diarrhea in a wide variety of mammals and birds. On the surface of the viral capsid are globular spikes that are thought to be involved in attachment to host cells. To understand the basis of species specificity, we investigated the structure of an avian astrovirus capsid ...

Functional and evolutionary insight from the crystal structure of rubella virus protein E1.

DuBois, Rebecca M Vaney, Marie-Christine Tortorici, M Alejandra Kurdi, Rana Al Barba-Spaeth, Giovanna Krey, Thomas Rey, Félix A

Published in Nature

Little is known about the three-dimensional organization of rubella virus, which causes a relatively mild measles-like disease in children but leads to serious congenital health problems when contracted in utero. Although rubella virus belongs to the same family as the mosquito-borne alphaviruses, in many respects it is more similar to other aeroso...

The Sequencing Bead Array (SBA), a next-generation digital suspension array. PDF available through Get Fulltext Research

Akhras, Michael S Pettersson, Erik Diamond, Lisa Unemo, Magnus Okamoto, Jennifer Davis, Ronald W Pourmand, Nader

Published in PloS one

Here we describe the novel Sequencing Bead Array (SBA), a complete assay for molecular diagnostics and typing applications. SBA is a digital suspension array using Next-Generation Sequencing (NGS), to replace conventional optical readout platforms. The technology allows for reducing the number of instruments required in a laboratory setting, where ...

Evaluation of ProExC as a prognostic marker in oropharyngeal squamous cell carcinomas.

Mills, Anne M Beck, Andrew H Pourmand, Nader Le, Quynh Thu Kong, Christina S

Published in The American journal of surgical pathology

ProExC expression has been shown to perform similarly to p16 as an aid in the diagnosis of cervical dysplasia but has not been well characterized in head and neck squamous cell carcinomas (SCC). The purpose of this study is to determine whether ProExC performs similarly to p16 as a prognostic marker in oropharyngeal SCC and to evaluate the threshol...

Polycyclic Aromatic Hydrocarbons as Plausible Prebiotic Membrane Components PDF available through Get Fulltext Research

Groen, Joost Deamer, David W. Kros, Alexander Ehrenfreund, Pascale

Published in Origins of Life and Evolution of Biospheres

Aromatic molecules delivered to the young Earth during the heavy bombardment phase in the early history of our solar system were likely to be among the most abundant and stable organic compounds available. The Aromatic World hypothesis suggests that aromatic molecules might function as container elements, energy transduction elements and templating...

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