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News 244 Publications 8 Members

Ultrasensitive mycotoxin detection by STING sensors.

Actis, Paolo Jejelowo, Olufisayo Pourmand, Nader

Published in Biosensors & bioelectronics

Signal transduction by ion nano-gating (STING) technology is a label-free biosensor capable of identifying DNA and proteins. Based on a functionalized quartz nanopipette, the STING sensor includes specific recognition elements for analyte discrimination based on size, shape and charge density. A key feature of this technology is that it does not re...

Herpes simplex virus glycoproteins H/L bind to cells independently of {alpha}V{beta}3 integrin and inhibit virus entry, ... PDF available through Get Fulltext Research

Gianni, Tatiana Cerretani, Arianna Dubois, Rebecca Salvioli, Stefano Blystone, Scott S Rey, Felix Campadelli-Fiume, Gabriella

Published in Journal of virology

Herpes simplex virus (HSV) fusion with cells requires the gD, gB, and gH/gL glycoprotein quartet. gD serves as a receptor binding glycoprotein. gB and gH/gL execute fusion in an as-yet-unclear manner. To better understand the role of gH/gL in HSV entry, we produced a soluble version of gH/gL carrying a One-STrEP tag (gH(t.st)/gL). Previous findings...

Detection of point mutations associated with antibiotic resistance in Pseudomonas aeruginosa.

N, Gorgani S, Ahlbrand A, Patterson N, Pourmand

Published in International Journal of Antimicrobial Agents

Excessive use of broad-spectrum antibiotics in hospitals has led to the emergence of highly resistant strains of Pseudomonas aeruginosa. To reduce the selection pressure for resistance, it is important to determine the antibiotic susceptibility pattern of bacteria so that hospital patients can be treated with more narrow-spectrum and target-specifi...

Ultrasensitive Qbeta phage analysis using fluorescence correlation spectroscopy on an optofluidic chip.

Rudenko, M I Kühn, S Lunt, E J Deamer, D W Hawkins, A R Schmidt, H

Published in Biosensors & bioelectronics

We demonstrate detection and analysis of the Qbeta bacteriophage on the single virus level using an integrated optofluidic biosensor. Individual Qbeta phages with masses on the order of attograms were sensed and analyzed on a silicon chip in their natural liquid environment without the need for virus immobilization. The diffusion coefficient of the...

The relationship between human papillomavirus status and other molecular prognostic markers in head and neck squamous ce...

Kong, Christina S Narasimhan, Balasubramanian Cao, Hongbin Kwok, Shirley Erickson, Julianna P Koong, Albert Pourmand, Nader Le, Quynh-Thu

Published in International journal of radiation oncology, biology, physics

To evaluate the relationship between human papillomavirus (HPV) status and known prognostic makers for head and neck cancers including tumor hypoxia, epidermal growth factor receptor (EGFR) expression and intratumoral T-cell levels and to determine the prognostic impact of these markers by HPV status. HPV status in 82 evaluable head and neck squamo...

Amino acid residues in the fusion peptide pocket regulate the pH of activation of the H5N1 influenza virus hemagglutinin... PDF available through Get Fulltext Research

Reed, Mark L Yen, Hui-Ling DuBois, Rebecca M Bridges, Olga A Salomon, Rachelle Webster, Robert G Russell, Charles J

Published in Journal of virology

The receptor specificity and cleavability of the hemagglutinin (HA) protein have been shown to regulate influenza A virus transmissibility and pathogenicity, but little is known about how its pH of activation contributes to these important biological properties. To identify amino acid residues that regulate the acid stability of the HA protein of H...

Label-free biosensing with functionalized nanopipette probes.

Umehara, Senkei Karhanek, Miloslav Davis, Ronald W Pourmand, Nader

Published in Proceedings of the National Academy of Sciences of the United States of America

Nanopipette technology can uniquely identify biomolecules such as proteins based on differences in size, shape, and electrical charge. These differences are determined by the detection of changes in ionic current as the proteins interact with the nanopipette tip coated with probe molecules. Here we show that electrostatic, biotin-streptavidin, and ...

Multiplex protein assays based on real-time magnetic nanotag sensing.

Osterfeld, Sebastian J Yu, Heng Gaster, Richard S Caramuta, Stefano Xu, Liang Han, Shu-Jen Hall, Drew A Wilson, Robert J Sun, Shouheng White, Robert L ...

Published in Proceedings of the National Academy of Sciences of the United States of America

Magnetic nanotags (MNTs) are a promising alternative to fluorescent labels in biomolecular detection assays, because minute quantities of MNTs can be detected with inexpensive giant magnetoresistive (GMR) sensors, such as spin valve (SV) sensors. However, translating this promise into easy to use and multilplexed protein assays, which are highly so...

The potential and challenges of nanopore sequencing.

D, Branton Dw, Deamer A, Marziali H, Bayley Sa, Benner T, Butler M, Di Ventra S, Garaj A, Hibbs X, Huang ...

Published in Nature Biotechnology

A nanopore-based device provides single-molecule detection and analytical capabilities that are achieved by electrophoretically driving molecules in solution through a nano-scale pore. The nanopore provides a highly confined space within which single nucleic acid polymers can be analyzed at high throughput by one of a variety of means, and the perf...

Suspension bead array branch migration displacement assay for rapid STR analysis.

Villablanca, Andrea Karhanek, Miloslav Caramuta, Stefano Yu, Heng Jejelowo, Olufisayo Webb, Chris D Pourmand, Nader

Published in Electrophoresis

STR analysis is commonly used in forensic and genetic studies. STRs are currently discriminated based on size, primarily by gel- and column-based approaches. Hybridization-based approaches have the potential to allow high-throughput analysis of STRs; however, development of such approaches has been limited by the difficulty in discriminating betwee...

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