UC Santa Cruz Nanotechnology Cluster
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News 244 Publications 8 Members

The receptor-binding domain of influenza virus hemagglutinin produced in Escherichia coli folds into its native, immunog...

Rebecca Dubois Aguilar-Yañez, Jm Mendoza-Ochoa, Gi Oropeza-Almazán, Y Schultz-Cherry, S Alvarez, Mm White, Sw Russell, Cj

Published in Journal of Virology

The hemagglutinin (HA) surface glycoprotein promotes influenza virus entry and is the key protective antigen in natural immunity and vaccines. The HA protein is a trimeric envelope glycoprotein consisting of a globular receptor-binding domain (HA-RBD) that is inserted into a membrane fusion-mediating stalk domain. Similar to other class I viral fus...

Microsecond time-scale discrimination among polycytidylic acid, polyadenylic acid, and polyuridylic acid as homopolymers...

Mark Akeson Branton, D Kasianowicz, Jj Brandin, E David Deamer

Published in Biophysical Journal

Single molecules of DNA or RNA can be detected as they are driven through an alpha-hemolysin channel by an applied electric field. During translocation, nucleotides within the polynucleotide must pass through the channel pore in sequential, single-file order because the limiting diameter of the pore can accommodate only one strand of DNA or RNA at ...

Highly-multiplexed barcode sequencing: an efficient method for parallel analysis of pooled samples.

Smith, Am Heisler, Le St Onge, Rp Farias-Hesson, E Wallace, Im Bodeau, J Harris, An Perry, Km Giaever, G Nader Pourmand ...

Published in Nucleic Acids Research

Next-generation sequencing has proven an extremely effective technology for molecular counting applications where the number of sequence reads provides a digital readout for RNA-seq, ChIP-seq, Tn-seq and other applications. The extremely large number of sequence reads that can be obtained per run permits the analysis of increasingly complex samples...

Spin valve sensors for ultrasensitive detection of superparamagnetic nanoparticles for biological applications.

Li, G Sun, S Wilson, Rj White, Rl Nader Pourmand Wang, Sx

Published in Sensors and Actuators A Physical

We present giant magnetoresistance (GMR) spin valve sensors designed for detection of superparamagnetic nanoparticles as potential biomolecular labels in magnetic biodetection technology. We discuss the sensor design and experimentally demonstrate that as few as approximately 23 monodisperse 16-nm superparamagnetic Fe(3)O(4) nanoparticles can be de...

Voltage-controlled metal binding on polyelectrolyte-functionalized nanopores.

Actis, P Vilozny, B Seger, Ra Li, X Jejelowo, O Rinaudo, M Nader Pourmand

Published in Langmuir

Most of the research in the field of nanopore-based platforms is focused on monitoring ion currents and forces as individual molecules translocate through the nanopore. Molecular gating, however, can occur when target analytes interact with receptors appended to the nanopore surface. Here we show that a solid state nanopore functionalized with poly...

Frac-seq reveals isoform-specific recruitment to polyribosomes.

Sterne-Weiler, T Martinez-Nunez, Rt Howard, Jm Cvitovik, I Katzman, S Tariq, Ma Nader Pourmand Sanford, Jr

Published in Genome Research

Pre-mRNA splicing is required for the accurate expression of virtually all human protein coding genes. However, splicing also plays important roles in coordinating subsequent steps of pre-mRNA processing such as polyadenylation and mRNA export. Here, we test the hypothesis that nuclear pre-mRNA processing influences the polyribosome association of ...

Hydrothermal Conditions and the Origin of Cellular Life.

David Deamer Georgiou, Cd

Published in International Journal of Astrobiology

The conditions and properties of hydrothermal vents and hydrothermal fields are compared in terms of their ability to support processes related to the origin of life. The two sites can be considered as alternative hypotheses, and from this comparison we propose a series of experimental tests to distinguish between them, focusing on those that invol...

Evidence that sensitivity to steroid anesthetics appears late in evolution.

Oliver, Ae David Deamer Mark Akeson

Published in Brain Research

The effects of pregnanolone, a steroid anesthetic, were compared with diethyl ether and short chain alkanols in 21 aquatic species from 7 phyla. Loss of righting reflex and escape response were used as indicators of anesthesia. All organisms were anesthetized by diethyl ether and short chain alkanols, but pregnanolone affected only organisms belong...

Atomic structure, adsorbate ordering, and mode of growth of the K/Si(100)2 x 1 surface.

Soukiassian, P Joel Kubby Mangat, P Hurych, Z Schirm, Km

Published in Physical Review B

Lipids as universal biomarkers of extraterrestrial life.

Georgiou, Cd David Deamer

Published in International Journal of Astrobiology

In 1965, James Lovelock published a general statement, based on thermodynamic chemical equilibrium principles, about how to detect extant or extinct life on a planet other than Earth. Nearly 50 years later, it is possible to make such measurements with robotic missions such as current and future Mars rovers, and probes to sample icy plumes of Encel...

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