UC Santa Cruz Nanotechnology Cluster
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News 244 Publications 8 Members

Stability of Model Membranes in Extreme Environments

Namani, Trishool Deamer, David W.

Published in Origins of Life and Evolution of Biospheres

The first forms of cellular life required a source of amphiphilic compounds capable of assembling into stable boundary structures. Membranes composed of fatty acids have been proposed as model systems of primitive membranes, but their bilayer structure is stable only within a narrow pH range and low ionic strength. They are particularly sensitive t...

Giant magnetoresistive biochip for DNA detection and HPV genotyping.

L, Xu H, Yu Ms, Akhras Sj, Han S, Osterfeld Rl, White N, Pourmand Sx, Wang

Published in Biosensors and Bioelectronics

A giant magnetoresistive (GMR) biochip based on spin valve sensor array and magnetic nanoparticle labels was developed for inexpensive, sensitive and reliable DNA detection. The DNA targets detected in this experiment were PCR products amplified from Human Papillomavirus (HPV) plasmids. The concentrations of the target DNA after PCR were around 10 ...

Simultaneous measurement of nonlinearity and electrochemical impedance for protein sensing using two-tone excitation.

Daniels, Jonathan S Anderson, Erik P Lee, Thomas H Pourmand, Nader

Published in Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference

Impedance biosensors detect the binding of a target to an immobilized probe by quantifying changes in the impedance of the electrode-electrolyte interface. The interface's I-V relationship is inherently nonlinear, varying with DC bias, and target binding can alter the degree of nonlinearity. We propose and demonstrate a method to simultaneously mea...

Sequence-specific detection of individual DNA polymerase complexes in real time using a nanopore.

Benner, Seico Chen, Roger J A Wilson, Noah A Abu-Shumays, Robin Hurt, Nicholas Lieberman, Kate R Deamer, David W Dunbar, William B Akeson, Mark

Published in Nature nanotechnology

Nanoscale pores have potential to be used as biosensors and are an established tool for analysing the structure and composition of single DNA or RNA molecules. Recently, nanopores have been used to measure the binding of enzymes to their DNA substrates. In this technique, a polynucleotide bound to an enzyme is drawn into the nanopore by an applied ...

Electron interferometry at a metal-semiconductor interface.

Joel Kubby Wj, Greene

Published in Physical Review Letters

Microsecond time-scale discrimination among polycytidylic acid, polyadenylic acid, and polyuridylic acid as homopolymers...

Mark Akeson Branton, D Kasianowicz, Jj Brandin, E David Deamer

Published in Biophysical Journal

Single molecules of DNA or RNA can be detected as they are driven through an alpha-hemolysin channel by an applied electric field. During translocation, nucleotides within the polynucleotide must pass through the channel pore in sequential, single-file order because the limiting diameter of the pore can accommodate only one strand of DNA or RNA at ...

Highly-multiplexed barcode sequencing: an efficient method for parallel analysis of pooled samples. PDF available through Get Fulltext Research

Smith, Am Heisler, Le St Onge, Rp Farias-Hesson, E Wallace, Im Bodeau, J Harris, An Perry, Km Giaever, G Nader Pourmand ...

Published in Nucleic Acids Research

Next-generation sequencing has proven an extremely effective technology for molecular counting applications where the number of sequence reads provides a digital readout for RNA-seq, ChIP-seq, Tn-seq and other applications. The extremely large number of sequence reads that can be obtained per run permits the analysis of increasingly complex samples...

Giant Magnetoresistive Sensors for DNA Microarray.

Xu, L Yu, H Han, Sj Osterfeld, S White, Rl Nader Pourmand Wang, Sx

Published in IEEE Transactions on Magnetics

Giant magnetoresistive (GMR) sensors are developed for a DNA microarray. Compared with the conventional fluorescent sensors, GMR sensors are cheaper, more sensitive, can generate fully electronic signals, and can be easily integrated with electronics and microfluidics. The GMR sensor used in this work has a bottom spin valve structure with an MR ra...

Proton permeation of lipid bilayers.

David Deamer

Published in Journal of Bioenergetics and Biomembranes

Proton permeation of the lipid bilayer barrier has two unique features. First, permeability coefficients measured at neutral pH ranges are six to seven orders of magnitude greater than expected from knowledge of other monovalent cations. Second, proton conductance across planar lipid bilayers varies at most by a factor of 10 when pH is varied from ...

Spin valve sensors for ultrasensitive detection of superparamagnetic nanoparticles for biological applications.

Li, G Sun, S Wilson, Rj White, Rl Nader Pourmand Wang, Sx

Published in Sensors and Actuators A Physical

We present giant magnetoresistance (GMR) spin valve sensors designed for detection of superparamagnetic nanoparticles as potential biomolecular labels in magnetic biodetection technology. We discuss the sensor design and experimentally demonstrate that as few as approximately 23 monodisperse 16-nm superparamagnetic Fe(3)O(4) nanoparticles can be de...

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