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News 244 Publications 8 Members

Water transport by the bacterial channel alpha-hemolysin.

Paula, S Mark Akeson David Deamer

Published in Biochimica et Biophysica Acta

This study is an investigation of the ability of the bacterial channel alpha-hemolysin to facilitate water permeation across biological membranes. alpha-Hemolysin channels were incorporated into rabbit erythrocyte ghosts at varying concentrations, and water permeation was induced by mixing the ghosts with hypertonic sucrose solutions. The resulting...

The receptor-binding domain of influenza virus hemagglutinin produced in Escherichia coli folds into its native, immunog... PDF available through Get Fulltext Research

Rebecca Dubois Aguilar-Yañez, Jm Mendoza-Ochoa, Gi Oropeza-Almazán, Y Schultz-Cherry, S Alvarez, Mm White, Sw Russell, Cj

Published in Journal of Virology

The hemagglutinin (HA) surface glycoprotein promotes influenza virus entry and is the key protective antigen in natural immunity and vaccines. The HA protein is a trimeric envelope glycoprotein consisting of a globular receptor-binding domain (HA-RBD) that is inserted into a membrane fusion-mediating stalk domain. Similar to other class I viral fus...

Hydrothermal Conditions and the Origin of Cellular Life.

David Deamer Georgiou, Cd

Published in International Journal of Astrobiology

The conditions and properties of hydrothermal vents and hydrothermal fields are compared in terms of their ability to support processes related to the origin of life. The two sites can be considered as alternative hypotheses, and from this comparison we propose a series of experimental tests to distinguish between them, focusing on those that invol...

Evidence that sensitivity to steroid anesthetics appears late in evolution.

Oliver, Ae David Deamer Mark Akeson

Published in Brain Research

The effects of pregnanolone, a steroid anesthetic, were compared with diethyl ether and short chain alkanols in 21 aquatic species from 7 phyla. Loss of righting reflex and escape response were used as indicators of anesthesia. All organisms were anesthetized by diethyl ether and short chain alkanols, but pregnanolone affected only organisms belong...

Atomic structure, adsorbate ordering, and mode of growth of the K/Si(100)2 x 1 surface.

Soukiassian, P Joel Kubby Mangat, P Hurych, Z Schirm, Km

Published in Physical Review B

Formation of carbon-carbon bonds in the photochemical alkylation of polycyclic aromatic hydrocarbons.

Mahajan, Tb Elsila, Je David Deamer Zare, Rn

Published in Origins of Life and Evolution of Biospheres

The reaction of polycyclic aromatic hydrocarbons (PAHs) with alkanes was examined in the presence of ultraviolet (UV) light under model prebiotic Earth and interstellar medium (ISM) conditions. We observed the formation of alkylated PAHs from a variety of PAHs and alkanes, which was caused by the absorption of UV light by the PAH molecule. Photoalk...

Lipids as universal biomarkers of extraterrestrial life.

Georgiou, Cd David Deamer

Published in International Journal of Astrobiology

In 1965, James Lovelock published a general statement, based on thermodynamic chemical equilibrium principles, about how to detect extant or extinct life on a planet other than Earth. Nearly 50 years later, it is possible to make such measurements with robotic missions such as current and future Mars rovers, and probes to sample icy plumes of Encel...

Antiviral susceptibility of avian and swine influenza virus of the N1 neuraminidase subtype. PDF available through Get Fulltext Research

Stoner, Td Krauss, S Rebecca Dubois Negovetich, Nj Stallknecht, De Senne, Da Gramer, Mr Swafford, S Deliberto, T Govorkova, Ea ...

Published in Journal of Virology

Influenza viruses of the N1 neuraminidase (NA) subtype affecting both animals and humans caused the 2009 pandemic. Anti-influenza virus NA inhibitors are crucial early in a pandemic, when specific influenza vaccines are unavailable. Thus, it is urgent to confirm the antiviral susceptibility of the avian viruses, a potential source of a pandemic vir...

Lamellar and hexagonal lipid phases visualized by freeze-etching.

David Deamer Leonard, R Tardieu, A Branton, D

Published in Biochimica et Biophysica Acta

Protease digestion of membranes. Ultrastructural and biochemical effects.

Yamanaka, N David Deamer

Published in Biochimica et Biophysica Acta

(1) Nagarse, a bacterial protease, was permitted to react with sarcoplasmic reticulum, submitochondrial and plasma membranes. Gel electrophoresis indicated that all polypeptides were labile to the enzyme, and therefore must be at least partially exposed at membrane surfaces. However, hydrolysis did not proceed to completion, and in each membrane 30...

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