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Compartmental genomics in living cells revealed by single-cell nanobiopsy.

Actis, Paolo Maalouf, Michelle M Kim, Hyunsung John Lohith, Akshar Vilozny, Boaz Seger, R Adam Pourmand, Nader

Published in ACS nano

The ability to study the molecular biology of living single cells in heterogeneous cell populations is essential for next generation analysis of cellular circuitry and function. Here, we developed a single-cell nanobiopsy platform based on scanning ion conductance microscopy (SICM) for continuous sampling of intracellular content from individual ce...

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