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Compartmental genomics in living cells revealed by single-cell nanobiopsy. PDF of an alternative version is available through Get Fulltext Research

Actis, Paolo Maalouf, Michelle M Kim, Hyunsung John Lohith, Akshar Vilozny, Boaz Seger, R Adam Pourmand, Nader

Published in ACS nano

The ability to study the molecular biology of living single cells in heterogeneous cell populations is essential for next generation analysis of cellular circuitry and function. Here, we developed a single-cell nanobiopsy platform based on scanning ion conductance microscopy (SICM) for continuous sampling of intracellular content from individual ce...

Dynamic control of nanoprecipitation in a nanopipette. PDF available through Get Fulltext Research

Vilozny, Boaz Actis, Paolo Seger, R Adam Pourmand, Nader

Published in ACS nano

Studying the earliest stages of precipitation at the nanoscale is technically challenging but quite valuable as such phenomena reflect important processes such as crystallization and biomineralization. Using a quartz nanopipette as a nanoreactor, we induced precipitation of an insoluble salt to generate oscillating current blockades. The reversible...

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