Steady-state catecholamine distribution in chromaffin granule preparations: a test of the pump-leak hypothesis of genera...
Published in Biochemistry
The molecular mechanism of general anesthesia is not understood. Possible modes of action include binding at a protein site, such as a receptor or channel, or physical effects on membrane lipid properties. The pump-leak hypothesis suggests that anesthetics perturb the bilayer of synaptic vesicles, thereby increasing ionic permeability. This results...