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Reversible thrombin detection by aptamer functionalized STING sensors.

Actis, P Rogers, A Nivala, J Vilozny, B Seger, Ra Jejelowo, O Nader Pourmand

Published in Biosensors and Bioelectronics

Signal Transduction by Ion NanoGating (STING) is a label-free technology based on functionalized quartz nanopipettes. The nanopipette pore can be decorated with a variety of recognition elements and the molecular interaction is transduced via a simple electrochemical system. A STING sensor can be easily and reproducibly fabricated and tailored at t...

Controlled gating and electrical detection of single 50S ribosomal subunits through a solid-state nanopore in a microflu...

Rudenko, Mi Holmes, Mr Ermolenko, Dn Lunt, Ej Gerhardt, S Noller, Hf David Deamer Hawkins, A Holger Schmidt

Published in Biosensors and Bioelectronics

We describe analysis and control of 50S ribosomal subunits by a solid-state 45nm diameter nanopore incorporated in a microfluidic chip. When used as a resistive pulse sensor, translocation of single 50S subunits through the nanopore produces current blockades that have a linear dependence on applied voltage. Introduction of individual subunits into...

Sensitive giant magnetoresistive-based immunoassay for multiplex mycotoxin detection.

Mak, Ac Osterfeld, Sj Yu, H Wang, Sx Davis, Rw Jejelowo, Oa Nader Pourmand

Published in Biosensors and Bioelectronics

Rapid and multiplexed measurement is vital in the detection of food-borne pathogens. While highly specific and sensitive, traditional immunochemical assays such as enzyme-linked immunosorbent assays (ELISAs) often require expensive read-out equipment (e.g. fluorescent labels) and lack the capability of multiplex detection. By combining the superior...

Giant magnetoresistive biochip for DNA detection and HPV genotyping.

L, Xu H, Yu Ms, Akhras Sj, Han S, Osterfeld Rl, White N, Pourmand Sx, Wang

Published in Biosensors and Bioelectronics

A giant magnetoresistive (GMR) biochip based on spin valve sensor array and magnetic nanoparticle labels was developed for inexpensive, sensitive and reliable DNA detection. The DNA targets detected in this experiment were PCR products amplified from Human Papillomavirus (HPV) plasmids. The concentrations of the target DNA after PCR were around 10 ...

Ultrasensitive mycotoxin detection by STING sensors.

Actis, Paolo Jejelowo, Olufisayo Pourmand, Nader

Published in Biosensors & bioelectronics

Signal transduction by ion nano-gating (STING) technology is a label-free biosensor capable of identifying DNA and proteins. Based on a functionalized quartz nanopipette, the STING sensor includes specific recognition elements for analyte discrimination based on size, shape and charge density. A key feature of this technology is that it does not re...

Ultrasensitive Qbeta phage analysis using fluorescence correlation spectroscopy on an optofluidic chip.

Rudenko, M I Kühn, S Lunt, E J Deamer, D W Hawkins, A R Schmidt, H

Published in Biosensors & bioelectronics

We demonstrate detection and analysis of the Qbeta bacteriophage on the single virus level using an integrated optofluidic biosensor. Individual Qbeta phages with masses on the order of attograms were sensed and analyzed on a silicon chip in their natural liquid environment without the need for virus immobilization. The diffusion coefficient of the...

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