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Multiplex protein assays based on real-time magnetic nanotag sensing.

Osterfeld, Sebastian J Yu, Heng Gaster, Richard S Caramuta, Stefano Xu, Liang Han, Shu-Jen Hall, Drew A Wilson, Robert J Sun, Shouheng White, Robert L ...

Published in Proceedings of the National Academy of Sciences of the United States of America

Magnetic nanotags (MNTs) are a promising alternative to fluorescent labels in biomolecular detection assays, because minute quantities of MNTs can be detected with inexpensive giant magnetoresistive (GMR) sensors, such as spin valve (SV) sensors. However, translating this promise into easy to use and multilplexed protein assays, which are highly so...

Structure of a core fragment of glycoprotein H from pseudorabies virus in complex with antibody.

Backovic, Marija DuBois, Rebecca M Cockburn, Joseph J Sharff, Andrew J Vaney, Marie-Christine Granzow, Harald Klupp, Barbara G Bricogne, Gerard Mettenleiter, Thomas C Rey, Felix A ...

Published in Proceedings of the National Academy of Sciences of the United States of America

Compared with many well-studied enveloped viruses, herpesviruses use a more sophisticated molecular machinery to induce fusion of viral and cellular membranes during cell invasion. This essential function is carried out by glycoprotein B (gB), a class III viral fusion protein, together with the heterodimer of glycoproteins H and L (gH/gL). In pseud...

Label-free biosensing with functionalized nanopipette probes.

Umehara, Senkei Karhanek, Miloslav Davis, Ronald W Pourmand, Nader

Published in Proceedings of the National Academy of Sciences of the United States of America

Nanopipette technology can uniquely identify biomolecules such as proteins based on differences in size, shape, and electrical charge. These differences are determined by the detection of changes in ionic current as the proteins interact with the nanopipette tip coated with probe molecules. Here we show that electrostatic, biotin-streptavidin, and ...

Single-cell analyses of transcriptional heterogeneity during drug tolerance transition in cancer cells by RNA sequencing...

Lee, Mei-Chong Wendy Lopez-Diaz, Fernando J Khan, Shahid Yar Tariq, Muhammad Akram Dayn, Yelena Vaske, Charles Joseph Radenbaugh, Amie J Kim, Hyunsung John Emerson, Beverly M Pourmand, Nader ...

Published in Proceedings of the National Academy of Sciences of the United States of America

The acute cellular response to stress generates a subpopulation of reversibly stress-tolerant cells under conditions that are lethal to the majority of the population. Stress tolerance is attributed to heterogeneity of gene expression within the population to ensure survival of a minority. We performed whole transcriptome sequencing analyses of met...

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