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A Novel Secreted Protein, MYR1, Is Central to Toxoplasma's Manipulation of Host Cells. PDF available through Get Fulltext Research

Franco, Magdalena Panas, Michael W Marino, Nicole D Lee, Mei-Chong Wendy Buchholz, Kerry R Kelly, Felice D Bednarski, Jeffrey J Sleckman, Barry P Pourmand, Nader Boothroyd, John C ...

Published in mBio

The intracellular protozoan Toxoplasma gondii dramatically reprograms the transcriptome of host cells it infects, including substantially up-regulating the host oncogene c-myc. By applying a flow cytometry-based selection to infected mouse cells expressing green fluorescent protein fused to c-Myc (c-Myc-GFP), we isolated mutant tachyzoites defectiv...

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